GAP43兔多克隆抗体

价格￥1200/￥1900
规格50ul/100ul
货号HK210152S/HK210152M
单位支
品牌HaoKebio

产品介绍

产品参数

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HK210152S	GAP43兔多克隆抗体	50ul	支	1200
HaoKebio	HK210152M	GAP43兔多克隆抗体	100ul	支	1900

Applications

Tested Applications:
IHC, IP, WB,ELISA

Cited Applications:
IF, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
canine, hamster, mouse, rat

Positive WB detected in:
mouse brain tissue, rat lung tissue, rat brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
mouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution:
WB : 1:2000-1:10000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
Product Information

Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.
Immunogen Information

Full name:
growth associated protein 43

Calculated molecular weight:
238 aa, 25 kDa

Observed molecular weight:
43 kDa

Gene symbol
GAP43

Synonyms
Axonal membrane protein GAP 43, B 50, GAP43, growth associated protein 43, Neural phosphoprotein B 50, Neuromodulin, PP46
Background
The neuronal growth-associated protein GAP43 is also known as neuromodulin, B-50, P-57, F1 and pp46. Deficiency of GAP43 in mice results in death early in the postnatal period. GAP43 is one of the main substrates for protein kinase C in the brain. GAP43 is an intracellular growth-associated protein that appears to assist neuronal pathfinding and branching during development and regeneration, and may contribute to presynaptic membrane changes in the adult, leading to the neurotransmitter release, endocytosis and synaptic vesicle recycling, long-term potentiation, spatial memory formation, and learning. The predicated molecular weight of about 25 kDa is much lower than the apparent observed molecular weight of 43 kDa on SDS-PAGE gels, and this occurs because the highly charged nature of GAP43 causes it to bind less than the average amount of SDS per amino acid, and because the protein has an elongated structure.

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