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Caspase 1兔多克隆抗体

Caspase 1兔多克隆抗体

一抗 抗体 试剂
  • 价格￥1200/￥2800
  • 规格50ul/200ul
  • 货号HK210063S/HK210063L
  • 单位支
  • 品牌HaoKebio
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产品介绍
产品参数
资料下载
品牌商品编码商品名称规格单位单价
HaoKebioHK210063SCaspase 1兔多克隆抗体50ul支1200
HaoKebioHK210063LCaspase 1兔多克隆抗体200ul支2800

Applications

Tested Applications:
IF, IHC, WB, ELISA

Cited Applications:
IF, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
bovine, human, monkey, mouse, pig, rat

Positive WB detected in:
RAW264.7, Jurkat cells, Raji cells, MCF-7 cells, HeLa cells, C6 cells, HepG2 cells, NIH/3T3 cells

Positive IHC detected in:
human spleen tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Positive IF detected in:
C6 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100
Product Information

Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Immunogen Information

Full name:
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Calculated molecular weight:
404 aa, 45 kDa

Observed molecular weight:
45-47 kDa, 30 kDa, 35 kDa

Gene symbol
CASP1

Synonyms
CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, p10, p20, P45
Background
CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.

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