Cited Applications: CoIP, IF, IHC, IP, WB Species Specificity: human, mouse, rat, pig
Cited Species: bovine, Chinese hamster ovary (CHO) cell, hamster, human, mouse, pig, rat, squirrel
Positive WB detected in: HeLa cells, SH-SY5Y cells, pig brain tissue, rat brain tissue, mouse heart tissue, rat heart tissue, mouse brain tissue, Jurkat cells, mouse spleen, rat spleen
Positive IP detected in: HeLa cells
Positive IHC detected in: rat brain tissue, human brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in: Hepa1-6 cells, HepG2 cells
Recommended dilution: WB : 1:500-1:3000 IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB IHC : 1:50-1:500 IF : 1:50-1:200 Product Information
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. Immunogen Information
Full name: fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Calculated molecular weight: 17 kDa
Observed molecular weight: 17 kDa
Gene symbol FIS1
Synonyms CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11 Background Fis1 (fission 1) is an integral mitochondrial outer membrane protein that participates in mitochondrial fission by interacting with dynamin-related protein 1 (Drp1). Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative or neurodevelopmental diseases. Increased expression of Fis1 has been found in Huntington’s disease (HD)-affected brain, Alzheimer’s disease (AD) patients, and autism spectrum disorder. This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates. (PMID: 21257639, 21459773, 23333625)
杭州浩克生物
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