Positive WB detected in: human brain tissue, human heart tissue, mouse kidney tissue, mouse lung tissue
Positive IHC detected in: human liver cancer tissue, human hepatocirrhosis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution: WB : 1:500-1:1000 IHC : 1:50-1:500 Product Information
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. Immunogen Information
Full name: thioredoxin domain containing 12 (endoplasmic reticulum)
Calculated molecular weight: 172 aa, 19 kDa
Observed molecular weight: 20 kDa, 40 kDa
Gene symbol TXNDC12
Synonyms AGR1, AIF, AIFM1, ERp18, ERp19, hAG 1, PDCD8, PDIA16, TLP19, TXNDC12 Background TXNDC12, which is known as thioredoxin domain-containing protein 12, ERp16, ERp18, ERp19, or hTLP19, is a member of the protein disulfide isomerase (PDI) family that plays important roles in cancer development and progression. TXNDC12 has been demonstrated to contribute to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion(PMID: 25940440). Other study also revealed the overexpression of TXNDC12 promotes HCC metastasis through β-catenin-mediated induction of EMT and that TXNDC12 has the potential to be a prognostic factor and therapeutic target of HCC.(PMID: 31570854)
杭州浩克生物
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