Positive IHC detected in: human gliomas tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in: PC-12 cells
Recommended dilution: WB : 1:500-1:2000 IHC : 1:200-1:800 IF : 1:50-1:500 Product Information
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. Immunogen Information
Full name: brain-derived neurotrophic factor
Calculated molecular weight: 247 aa, 28 kDa
Observed molecular weight: 28-30 kDa
Gene symbol BDNF
Synonyms Abrineurin, BDNF Background BDNF is a member of the family of neurotrophic factors. It was first explored and purified from pig brain in 1982, and other members of the neurotrophin family were successively discovered. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer’s and Huntington disease patients. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It also plays a role in the regulation of stress response and in the biology of mood disorders. The BDNF gene is rather complex in its structure and it can express five different mRNA isoforms by alternative splicing, producing 28-37 kDa proteins.
杭州浩克生物
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