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APOL1兔多克隆抗体

APOL1兔多克隆抗体

一抗 抗体 试剂
  • 价格￥1960/￥2800
  • 规格100ul/200ul
  • 货号HK210013M/HK210013L
  • 单位支
  • 品牌HaoKebio
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产品介绍
产品参数
资料下载
品牌商品编码商品名称规格单位单价
HaoKebioHK210013MAPOL1兔多克隆抗体100ul支1960
HaoKebioHK210013LAPOL1兔多克隆抗体200ul支2800

Applications

Tested Applications:
FC, IF, IHC, IP, WB, ELISA

Cited Applications:
IF, IHC, IP, WB
Species Specificity:
human

Cited Species:
human, mouse, Trypanosoma brucei

Positive WB detected in:
human blood tissue, A549 cells, SKOV-3 cells, HeLa cells, MCF-7 cells, HepG2 cells, A2780 cells, SW 1990 cells, human plasma tissue

Positive IP detected in:
HepG2 cells, human plasma tissue

Positive IHC detected in:
human kidney tissue, human spleen tissue, human liver tissue, human pancreas tissue, human testis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100
Product Information

Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Immunogen Information

Full name:
apolipoprotein L, 1

Calculated molecular weight:
44 kDa

Observed molecular weight:
39 kDa


Gene symbol
APOL1

Synonyms
APO L, APOL, APOL I, APOL1, Apolipoprotein L, Apolipoprotein L I, apolipoprotein L, 1, Apolipoprotein L1
Background
Human apolipo-protein L1 (APOL1) is a minor component of plasma high density lipoprotein (HDL) particles, acting as an interacting protein of apolipoprotein A1 (ApoA1). The human ApoL protein family was thought to be predominantly involved in lipid transport and metabolism. APOL1 is also involved in host innate immunity against Trypanosoma parasites. Once activated, APOL1 can lyse the parasite and protect human from infection. Genetic variants in APOL1 gene, which are found in African ancestry with high frequency, associate with chronic kidney disease, like focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. APOL1 share structural and functional similarities with proteins of the Bcl-2 family and may has roles in apoptosis and autophagy. It is notable that APOL1 exists only in human and a few other primate species, and mouse does not express an APOL1 orthologue. This antibody recognizes the endogenous APOL1 of 39-45 kDa in blood lysate.

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