CD31兔单克隆抗体

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKI0351A	CD31兔单克隆抗体	100ul	支	1313

Applications

Tested Applications:

IF, IHC, WB, ELISA

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Cited Applications:

IF, IHC, WB

Species Specificity:

Human

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Cited Species:

human

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Positive WB detected in:

human peripheral blood platelets, Jurkat cells, THP-1 cells

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Positive IHC detected in:

human liver cancer tissue, human breast cancer tissue, human tonsillitis tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

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Positive IF detected in:

human liver cancer tissue

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Recommended dilution:

WB : 1:5000-1:50000

IHC : 1:5000-1:20000

IF : 1:200-1:800

Product Information

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Source:

Mouse

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Purification method:

Protein A purification

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Isotype:

IgG1

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Aliquoting is unnecessary for -20^oC storage.

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Full name:

platelet/endothelial cell adhesion molecule

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Calculated molecular weight:

83 kDa

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Observed molecular weight:

120-130 kDa

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Gene symbol

PECAM1

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Synonyms

CD31, EndoCAM, FLJ58394, GPIIA, PECA1, PECAM 1, PECAM1, VEC marker

Background

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489)