CD30兔单克隆抗体

价格￥600
规格100ul
货号HKZ150128
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150128	CD30兔单克隆抗体	100ul	支	600

CD30
Recombinant Rabbit Monoclonal Antibody Product Datasheet

Catalog# BX50005 Clone# BP6012

Predicted Molecular Wt:
64kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P28908

Background:
CD30, TNF-receptor superfamily member, is a receptor for TNFSF8/CD30L. TRAF2 and TRAF5 can interact with this receptor and     mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and it
also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

CD30 is expressed in mononuclear Hodgkin’s and multinucleated Reed‐Sternberg cells in Hodgkin’s disease, in tumor cells of a majority of anaplastic large cell lymphomas, in a varying proportion of activated T and B cells. In non-lymphoid malignancies,   CD30 reactivity has been reported in embryonal carcinomas (ECs), seminomas, and hepatocellular carcinomas.

This antibody has been useful in identifying Hodgkin’s lymphoma, anaplastic large cell lymphomas (ALCL) and primary cutaneous CD30+ T-cell lymphoproliferative disorders.

Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CD30 residues within aa495‐C terminal of CD30 was used as an     immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Watanabe M., et al. Am J Pathol. 2003 Aug;163(2):633- 41.
2. Pileri SA., et al. J Clin Pathol. 2002 Mar;55(3):162-76.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded sections) analysis of human hodgkin
lymphoma tissue labelling  CD30 with BP6012. Heat     mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0