CA125兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150132
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150132	CA125兔单克隆抗体	100ul	支	1000

CA125
Recombinant Rabbit Monoclonal Antibody Product Datasheet

Catalog# BX50009 Clone# BP6014

Predicted Molecular Wt:
1519kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q8WXI7

Background:
CA125 (cancer antigen 125,carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16,  is a member of the
mucin family glycoproteins. CA125 is a component of the ocular surface (including the cornea and conjunctiva), the
respiratory tract and the female reproductive tract epithelia. Since CA125 is highly glycosylated it creates a hydrophilic   environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells.
CA125 reacts with both normal tissues and neoplasms of fallopian tube, endometrium, endocervix and mesothelioma. It does   not react with colon cancer. Normal tissues such as breast, liver, skin, kidney and spleen are also negative. Studies have shown that CA125 reacts with approximately 80% of epithelial ovarian neoplasms of serous, endometrioid, clear cell and
undifferentiated types. No reactivity has been shown for mucinous ovarian tumors or in germ cell or hematopoietic tumors.
This antibody is a useful aid for classification of a variety of tumors, such as some adenocarcinomas of the colon, breast carcinomas, malignant mesothelioma, uterine adenomatoid tumor, lung bronchoalveolar carcinoma, and ovarian
endometrioid and serous carcinomas.

Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CA125 residues within aa12201‐12300 of CA125 was used as an
immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Prat A., et al. Ann Oncol. 2008 Feb;19(2):327-31.

2. Tornos C., et al. Am J Surg Pathol. 2005 Nov;29(11):1482-9.