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| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150018 | CDX2兔单克隆抗体 | 100ul | 支 | 600 |
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150018 Clone# BP6023
Predicted Molecular Wt:
34kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity:
Human
Form: Liquid
Applications:
IHC-P
Swissprot ID: Q99626
Background:
CDX2 is a homeobox gene encoding nuclear homeodomain transcriptional factor essential to intestinal organogenesis. CDX2 is crucial for differentiation of epithelium in the intestine, pancreas and biliary tract. CDX2 interacts with the tumour suppressor genes APC and E-cadherin, as well asbcl-2.
In the intestine (from duodenum to rectum) CDX2 nuclear protein is demonstrated strongly and uniformly in all types of
epithelial cells. In pancreas and biliary tract CDX2 protein is demonstrated in scattered ductal cells. In tumor tissues, CDX2 is positive in the large majority cases of colorectal and appendicealadenocarcinomas.
CDX2 is a relatively sensitive and specific marker for “intestinal” adenocarcinomas. In the classification of (adeno‐)carcinomas of the unknown primary, CDX2 is an important marker but should always be included in a panel. Also in order to identify the origin of neuroendocrine tumors, CDX2 is useful in a panel.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CDX2 residues within aa1‐100 of CDX2 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P: 1:100-1:200
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections)
analysis of human colon
tissue labelling CDX2 with BP6023. Heat mediated
antigen retrieval was
performed using Tris/EDTA buffer pH 9.0
Background References:
1. Xin S, et.al,Oncology. 2007;73(5-6):357-65.
2. Werling RW, et.al,Am J Surg Pathol. 2003 Mar;27(3):303-10.
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