SOX10兔单克隆抗体

价格￥600
规格100ul
货号HKZ150142
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150142	SOX10兔单克隆抗体	100ul	支	600

SOX10
Recombinant Rabbit Monoclonal Antibody Product Datasheet

Catalog# BX50019 Clone# BP6024

Predicted Molecular Wt:
50kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P56693

Background:
SOX10 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. During development, SOX10 first appears in the forming neural crest and  continues to be expressed in Schwann cells. It is important for differentiation, maturation and maintenance of Schwann cells and melanocytes.

In normal tissues, SOX10 is expressed in Schwann cells and glial cells in the nervous system. It is also detected in melanocytes   and epithelial cells of salivary gland and mammary gland. In tumor tissues, SOX10 labels melanoma and tumors of neural crest origin.

SOX10 is more specific than S100 protein in the detection of melanocytic and schwannian neoplasms, and has in some studies shown more sensitive.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to SOX10 residues
within aa366‐466 of SOX10 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Ken Inoue,. et al. Human Molecular Genetics, 2007, Vol. 16, No. 24.
2. Nonaka D1,. et al. Am J Surg Pathol. 2008 Sep;32(9):1291-8.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) analysis of human
melanoma tissue labelling  SOX10 with BP6024. Heat mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0

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