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| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150145 | CD3兔单克隆抗体 | 100ul | 支 | 600 |
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50022 Clone# BP6027
Predicted Molecular Wt:
23kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity:
Human
Form: Liquid
Applications:
IHC-P
Swissprot ID: P07766
Background:
The CD3 protein is a T-cell marker,a complex of four structurally distinct membrane glycoprotein isoforms, comprising
extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating signal transduction to the internal environment upon antigenic recognition by TCR, causing T-cell proliferation and release of cytokines.
CD3 is found only in T-cells. In malignant lymphomas, CD3 is a pan-T-cell lineage-restricted antigen, detected in 80-97% of the T-cell lymphomas. Mature T-cell lymphomas including cases of mycosis fungoides, peripheral T-cell lymphoma and anaplastic large cell lymphoma may aberrantly lose CD3.
CD3 is an important marker in the classification of malignant lymphomas and lymphoid leukaemias.
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CD3E residues within aa1-100 of CD3E was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P: 1:100-1:200
Background References:
1. Walts AE,et.al, Diagn Cytopathol. 2012 Jul;40(7):565-9.
2. Hudacko R, et.al, Mod Pathol. 2013 Sep;26(9):1241-5.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of tonsil tissue labelling CD3 with BP6027. Heat mediated antigen retrieval was
performed using Tris/EDTA buffer pH 9.0
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