杭州浩克生物
ATRX兔单克隆抗体
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| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| HaoKebio | HKZ150147 | Granzyme B兔单克隆抗体 | 100ul | 支 | 1000 |
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50024 Clone# BP6029
Predicted Molecular Wt:
28kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity:
Human
Form: Liquid
Applications:
IHC-P
Swissprot ID: P10144
Background:
Granzyme B is serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Granzyme B is synthesized as inactive proenzymes, and they arestored within cytolytic granules and released by effector cells during degradation.
Recent studies have demonstrated that the expression of granzyme B by immunohistochemistry in several entities of extranodal peripheral T cell lymphoma (PTCL) and NK cell lymphomas, including nasal and nasal-type NK/T cell lymphomas, hepatosplenic
and non-hepatosplenic PTCL, enteropathy-type (ETCL) and non-ETCL intestinal PTCL, subcutaneous panniculitis-like PTCL (SPTCL), cutaneous CD8+ epidermotropic lymphomas as well as in nodal and cutaneous CD30+ anaplastic large cell lymphomas (ALCL).
The expression of cytotoxic proteins, such as granzyme B may be important for the identification and classification of extranodal T- and NK-cell lymphomas since many of these tumors do not have specific morphology and phenotype.
Subcellular location:
Cytoplasm
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to Granzyme B
residues within aa100-200 of Granzyme B was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P: 1:100-1:200
Background References:
1. Froelich CJ, et.al, J Immunol. 1993 Dec 15;151(12):7161-71.
2. Hodge G, et.al, Clin Exp Immunol. 2014 Oct;178(1):79- 85.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis of spleen tissue labelling granzyme B with BP6029. Heat
mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0
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