p40兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150151
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150151	p40兔单克隆抗体	100ul	支	1000

p40
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50028 Clone# BP6033
Predicted Molecular Wt:
66kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q9H3D4-2
Background:
p40 antibody (antibody recognizing ΔNp63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential—a role that may be recapitulated in tumors
derived from these cells.
p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial),
basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymicepithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma.

p40 is equivalent to p63 insensitivity for lungsquamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as
squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to p40 residues     within aa1-100 of p40 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Nonaka D et.al, Am J Surg Pathol. 2012 Jun;36(6):895- 9.
2. Bishop JA et.al, Mod Pathol. 2012 Mar;25(3):405-15.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis of
prostate tissue labelling
p40 with BP6033. Heat
mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0

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