CD34兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150165
单位支
品牌HaoKebio

产品介绍

产品参数

资料下载

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150165	CD34兔单克隆抗体	100ul	支	1000

CD34
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50042 Clone# BP6047
Predicted Molecular Wt:
41kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P28906
Background:
CD34 (also named myeloid progenitor cell antigen) is a heavily glycosylated type I transmembrane protein. There are two
forms of the CD34 protein, resulting from alternative splicing. The functions of CD34 is largely unknown, but recent evidence suggests a role for CD34 in cell adhesion and inhibition of hematopoiesis. It is suggested that CD34 is a signalling molecule
involved in maintenance of a phenotypically plastic state in undifferentiated cells.
CD34 is found in most endothelia, expressed on the luminal surface and membrane processes interdigitating between
endothelial cells, but is absent from large veins and arteries. CD34 is furthermore expressed in fibroblast-like dendritic cells in, e.g., portal tracts of the liver, Peyer’s patches, and in healing wounds. In smooth muscle cells, a variable CD34 staining is
found. In tumor tissues, CD34 is detected in myeloid blasts in myelodysplastic syndrome and acute myeloid leukaemia in most cases as well as lymphoblasts in most cases of B-acute lymphoblastic leukaemia. Mature B- and T-cell lymphomas and
leukaemias are CD34 negative. The majority of vascular tumours, including haemangiosarcoma and Kaposi sarcoma are CD34 positive.
In a panel, CD34 staining is useful for the classification of myeloid and lymphoid neoplasms as well as spindle cell neoplasms (particularly identification of gastrointestinal stromal tumour and haemangiosarcoma).
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CD34 residues
within aa285-385 of CD34 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Baumheter S, et.al, Science. 1993 Oct 15;262(5132):436-8.
2. Fina L, et.al, Blood. 1990 Jun 15;75(12):2417-26.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of
kidney tissue labelling
CD34 with BP6047. Heat mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

HKZ150165_BP6047_CD34 下载

暂无