CD1a Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# BX50050 Clone# BP6055 Predicted Molecular Wt: 37kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: P06126 Background: CD1a is a member of the family group 1 CD1 proteins (CD1a, CD1b, and CD1c), which share the capacity to present microbial lipid antigens to T cells. CD1a is expressed predominantly on Langerhans cells (LCs), it can be expressed by T-cells under certain conditions. Immature thymocytes express CD1a, as do some T-cells involved in neoplastic conditions such as pre-lymphoblastic lymphomas/leukemias and follicular dendritic cell sarcoma. CD1a expression on pathogenic Langerhans cells (LCs) in LCH is regarded as a hallmark of this disease and may as a potential target for future therapeutic strategies against inflammatory skin diseases. Subcellular location: Membrane Recommended method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Synthetic peptide corresponding to CD1a residues within aa1-100 of CD1a was used as an immunogen. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage conditions: -25°C to -18°C Storage instructions: Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles. Recommended Dilutions: IHC-P: 1:100-1:200 Background References: 1. Hunger RE, et.al, J Clin Invest. 2004 Mar;113(5):701-8. 2. Ji Hyung Kim, et.al, Nature Immunology 17 (10) , pp. 1159-1166. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections analysis of esophagus tissue labelling CD1a with BP6055. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9.0
杭州浩克生物
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