CD163兔单克隆抗体

价格￥600
规格100ul
货号HKZ150181
单位支
品牌HaoKebio

产品介绍

产品参数

资料下载

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150181	CD163兔单克隆抗体	100ul	支	600

CD163
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50058 Clone# BP6063
Predicted Molecular Wt:
125kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q86VB7
Background:
CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory
functions.
CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenicdendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not
present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with
monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease,
Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans.
CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical,
spectrum of cells as CD68.
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to CD163 residues within aa1056-1156 of  CD163 was used as an
immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Garcia C, et al. Appl Immunohistochem Mol Morphol 2008, 16(5), 417-21.
2. Nguyen TT, et al. Am J Surg Pathol 2005, 29(5), 617-24.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of liver tissue labelling CD163
with BP6063. Heat
mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

HKZ150181_BP6063_ CD163 下载

暂无