SOX11兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150188
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150188	SOX11兔单克隆抗体	100ul	支	1000

SOX11
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50065 Clone# BP6070
Predicted Molecular Wt:
47kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P35716
Background:
SOX11 (SOX = SRY-related HMG box) is a nuclear transcription factor belonging to subgroup C of SRY (sex determining region on Y-chromosome) related HMG (high mobility group) box genes. It contains 2 functional domains: A HMG box DNA-binding  domain, located at the N-terminus, and a transactivation domain (TAD), located at the C-terminus.
SOX11 expression is critical for embryonic neurogenesis and tissue remodeling, it is normally expressed during the developing nervous system of human embryos and is required for neurite growth and neuron survival. Expression is seen in fetal tissues    (18-25 weeks) mainly in the brain. Outside the CNS SOX11 seems primarily to be expressed at sites of epithelial-mesenchymal interactions. SOX11 is not expressed in normal adult human tissues, and its over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases.
Currently the only diagnostic application is verification of mantle cell lymphomas, particularly the rare cyclin D1 negative cases.
Subcellular location:Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:Synthetic peptide corresponding to SOX11 residues
within aa300-400 of  SOX11 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Chen Y-H etal. Mod. Pathol. 2010;23(1):105–12.
2. Mozos A et al. Haematologica. 2009;94(11):1555–1562.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of
mantle zone cell
lymphoma tissue
labelling SOX11 with
BP6070. Heat mediated antigen retrieval was
performed using
Tris/EDTA buffer pH 9.0

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