CD45兔单克隆抗体

价格￥600
规格100ul
货号HKZ150191
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150191	CD45兔单克隆抗体	100ul	支	600

CD45
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50068 Clone# BP6073
Predicted Molecular Wt:
147kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P08575
Background:
CD45 is a family of single chain transmembrane glycoproteins, consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are rod shaped, heavily glycosylated. The different isoforms are produced by  alternative messenger RNA splicing of three exons of a single gene on chromosome 1q31-32.
CD45 is exclusively expressed in haematolymphoid cells. Almost all haematolymphoid cells, including precursor cells and
mature B- and T-lymphocytes, granulocytes, monocytes/histiocytes and interdigitating reticulum cells and follicular dendritic
cells express CD45. This protein is detected in the large majority of haematolymphoid neoplasms, i.e., leukemias and malignant lymphomas. Overall, about 90% of malignant lymphomas are CD45 positive.
CD45 is an important marker in the primary tumor screening panel in order to identify haematolymphoid differentiation. Loss of CD45 in precursor B-cell neoplasms is a negative prognostic parameter.
Subcellular location:Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant fragment within Human CD45 aa 1 to aa600.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Dahlke MH etal. Leuk Lymphoma. 2004 Feb;45(2):229- 36.
2. Gaertner EM  etal. Am J Clin Pathol. 2001 Apr;115(4):589-97.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of tonsil tissue labelling CD45
with BP6073. Heat mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

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普通病理

分子病理

成像分析

分子生物

理化检测

蛋白生物学

细胞实验

普通形态

分子病理

分子生物学

抗体

蛋白质生物学

CD45兔单克隆抗体

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