TTF-1兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150197
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150197	TTF-1兔单克隆抗体	100ul	支	1000

TTF-1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50074 Clone# BP6079
Predicted Molecular Wt:
39kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P43699
Background:
Thyroid transcription factor-1 (synonymes: Homeobox protein Nkx-2.1) is a 371 amino acid protein, 39 KDa,which belongs to   the NKX homeobox transcription factor family. TTF-1 stimulate or repress transcription of particular genes by binding to their    regulatory sequences.   TTF-1 plays a role in regulating genes in the thyroid, lung and brain. Its molecular targets in the thyroid gland are thyroglobulin, thyroperoxidase and thyrotropin receptor. TTF-1 activates transcription of the genes encoding these    proteins. In lung, TTF-1 promotes the transcription of the surfactant proteins A to D, and the Clara cell secretory protein. In
brain, the molecular targets of TTF-1 are unknown. Besides being a tissue-specific transcription promoter in adult organs, TTF- 1 has been suggested a role in morphogenesis and cytodifferentiation. Among thyroid neoplasms, TTF1 is seen in virtually all    tumours of follicular derivation.
In diagnostic pathology, TTF-1 is useful as marker for pulmonary adenocarcinoma and pulmonary neuroendocrine malignancy,
including small cell lung carcinoma. It can be used to differentiate primary lung adenocarcinoma from metastasis of extrapulmonary origin.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues within aa50-150 of  TTF-1 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Agoff SN, Lamps LW, Philip AT, et al.  Mod Pathol 2000,13:238-242.
2. Bingle CD. Int J Biochem Cell Biol 1997;29:1471-1473.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis of
thyroid labelling TTF-1 with BP6079. Heat
mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0.

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