Progesterone Receptor兔单克隆抗体

Progesterone Receptor兔单克隆抗体

  • 价格¥1000
  • 规格100ul
  • 货号HKZ150199
  • 单位
  • 品牌HaoKebio

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HaoKebioHKZ150199Progesterone Receptor兔单克隆抗体100ul1000
Progesterone Receptor
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  BX50076 Clone#  BP6081
Predicted Molecular Wt:
99kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P06401
Background:
Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the   formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis.  The cellular effects of progesterone are mediated through progesterone receptors (PR). PR,a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor superfamily of nuclear receptors. PR is predominantly  expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other
tissues such as endocrine cells of the Langerhans’ islets.
The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein corresponding to residues within aa400-600 of  progesterone receptor was used as an
immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:300-1:600
Background References:
1.  Bardou V-J, ArpinoG, Elledge RM, et al. J Clin Oncol 2003;21:1973-1979.
2.  Elledge RM, GreenS, Pugh R etal.  Int J Cancer 2000;89:111-117.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis of
breast cancer labelling progesterone receptor with BP6081. Heat
mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

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