Napsin A兔单克隆抗体

价格￥1000
规格100ul
货号HKZ150201
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150201	Napsin A兔单克隆抗体	100ul	支	1000

Napsin A
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50078 Clone# BP6083
Predicted Molecular Wt:
45kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  O96009
Background:
Napsin A is a pepsin-like aspartic proteinase contains 420 amino acids. It is predominantly expressed in the lung and kidney. In the lung, Napsin A is expressed in alveolar type II pneumocytes, regulated by TTF-1, and is involved in the generation of the
surfactant protein B. Intra-alveolar macrophages contain Napsin A as a result of phagocytosis. In the kidney, Napsin A is expressed in the proximal tubules, where it is involved in lysosomal protein catabolism.
Napsin A is important in the differential diagnosis of lung adenocarcinoma vs. squamous cell carcinoma, used in a panel with TTF-1, CK5 and p63. For tumours presenting as adenocarcinoma of unknown origin, the identification of a lung origin may be aided by NapA together with TTF1, and renal origin by NapA together with PAX8.
Subcellular location:
Cytoplasm
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues within aa50-150 of Napsin A was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. AgackiranY, Ozcan A, Akyurek N, Memis L. Appl
Immunohistochem Mol Morphol. 2012 Jul;20(4):350-5.
2. Chernock RD, El-Mofty SK, Becker N, Lewis JS Jr. Am J Surg Pathol. 2013 May 15.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis of lung adenocarcinoma
labelling Napsin A with   BP6083. Heat mediated antigen retrieval was
performed using
Tris/EDTA buffer pH 9.0.

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