ZAP-70兔单克隆抗体

价格¥600
规格100ul
货号HKZ150224
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150224	ZAP-70兔单克隆抗体	100ul	支	600

ZAP-70
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50101 Clone# BP6106
Predicted Molecular Wt:
70kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P43403
Background:
Zeta-associated protein-70 (ZAP-70) is a member of the Syk family of tyrosine kinases, a group of proteins that attach to the
zeta chain componentsofT-cell receptors to signal downstream events involved in the regulation of cell function,
proliferation, and death. Research suggests that the ZAP-70 protein may also play an important role in natural killer (NK) cell   activation and early B-cell development; however, it is not expressed in most normal mature B-cells. Expression of ZAP-70 has been reported in various lymphomas, including mantle cell lymphoma, small lymphocytic lymphoma and marginal zone
lymphoma. During thymocyte development, ZAP-70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP-70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR).
Subcellular location:
Nuclear and cytoplasmic
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues within
aa200-350 of ZAP-70 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA
0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store
at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:IHC-P:     1:100-1:200
Background References:
1. Crespo, et al.N Engl J Med. 2003 May 1;348(18):1764-75.
2. National Committee for Clinical Laboratory Standards(NCCLS). Villanova, PA 1991;7(9). Order code M29-P.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded sections analysis
of tonsil tissue labelling ZAP-70 with BP6106.
Heat mediated antigen
retrieval was performed
using Tris/EDTA buffer
pH 9.0

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