SOX2 Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# BX50119 Clone# BP6123 Predicted Molecular Wt: 34kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: P48431 Background: The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors. SOX2 is expressed in multipotent neuronal stem cells, and may aid to identify cells that are capable of self-renewal and multipotent differentiation. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lungsquamous cell carcinomas and was shown to bean independent positive prognostic marker.Subcellular location: Nucleus Recommended method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Synthetic peptide corresponding to residues within aa1-100 of Human SOX2 was used as an immunogen. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage conditions: -25°C to -18°C Storage instructions: Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles. Recommended Dilutions: IHC-P: 1:100-1:200 Background References: 1. Yang F, et al. Int J Clin Exp Pathol. 2013 Nov 15; 6 (12):2846-54. 2. Wilbertz T, et al. Mod Pathol. 2011 Jul; 24 (7):944-53. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Lung squamous cell carcinomas tissue labelling SOX2 with BP6123. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9.0
杭州浩克生物
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