ERG兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150246
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150246	ERG兔单克隆抗体	100ul	支	1000

ERG
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50123 Clone# BP6127
Predicted Molecular Wt:
55kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P11308
Background:
ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually    expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells.
ERG is expressed in virtually allendothelial neoplasms including haemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal
tumour, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumour, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodemal tumour, chondrosarcoma,
osteosarcoma, and rhabdomyosarcoma.
For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover,     the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues within
aa450 to C-terminus of ERG was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Miettinen M. Histopathology. 2014 Jan;64(1):101-18.
2. Stockman DL, Mod Pathol. 2014 Apr;27(4):496-501.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis of
appendix labelling ERG with BP6127. Heat
mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0.

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