PD-L1兔单克隆抗体

价格¥2200
规格100ul
货号HKZ150260
单位支
品牌HaoKebio

产品介绍

产品参数

资料下载

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150260	PD-L1兔单克隆抗体	100ul	支	2200

PD-L1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50137 Clone# BP6141
Predicted Molecular Wt:
33kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q9NZQ7
Background:
Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its   receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy
tissue allografts, autoimmune disease and malignant transformation.
PD-L1 is expressed on resting T cells, B cells, DCs, and macrophages and is further up-regulated upon activation. PD-L1 is also
expressed on parenchymal cells, including vascular endothelial cells and pancreatic islet cells. The expression of PD-L1 has been    discovered in avariety of epithelial cancers such as non-small cell lung carcinoma (NSCLC), pancreatic cancer, esophageal cancer, squamous cell carcinomas of the head and neck, and renal cell carcinoma (RCC).
The use of IHC for protein identification, along with novel therapies, such as checkpoint inhibitors and vaccines, are generating new options for the treatment of cancer patients.
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant full length protein corresponding to
Human PD-L1 (extracellular). The immunogen contains the specific extracellular domain of huPD-L1 (F19-
T239).
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. MuenstS1, et al. Breast Cancer Res Treat. 2014 Jul;146(1):15-24.
2. Lim SH, et al. Expert Opin Biol Ther. 2016;16(3):397- 406.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis of
placenta tissue labelling
PD-L1 with BP6001. Heat    mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0

HKZ150260_BP6141_PDL1 下载

暂无