Beta -Catenin兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150304
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150304	Beta -Catenin兔单克隆抗体	100ul	支	1000

Beta-Catenin
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50181 Clone# BP6159
Predicted Molecular Wt:
86kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P35222
Background:
Beta-Catenin is a key regulatory protein in Wnt signaling,a pathway that transmits signals from the cytoplasm to the nucleus, turning on the expression of specific genes in the nucleus.Under normal conditions, Beta-Catenin exists mainly in the cell
membrane of normal cells, and gene mutations lead to accumulation in the nucleus. At present, Beta-Catenin gene mutation has been found in various tumors, such as colon cancer, lung cancer, prostate cancer, esophageal cancer, breast cancer, ovarian
cancer, endometrial cancer,familial adenomatous polyposis, solid pseudopapilloma of pancreas, etc. High levels of nucleus
positivityare seen in desmoid fibromatosis, isolated fibrous tumors, synovial sarcomas and endometrial stromal sarcomas, and carcinosarcomas. It is mainly used for the diagnosis, invasion and metastasis of malignant tumor.
Subcellular location:
Membrane & Cytoplasm & Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to Human Beta- Catenin was used as an immunogen. The exact
sequence is proprietary.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Li XG  et al. Toxicol Lett 305:19-31 (2019).
2. Xu H  etal. Oncol Rep 41:1180-1188 (2019).Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections analysis of
human  prostate tissue
labelling Beta-Catenin with BP6159. Heat mediated
antigen retrieval was
performed using Tris/EDTA
buffer pH 9.0

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