CD146兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150307
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150307	CD146兔单克隆抗体	100ul	支	1000

CD146
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50184 Clone# BP6162
Predicted Molecular Wt:
72kD
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P43121
Background:
CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system,thereby enhancing
hematogeneous tumor spread. Could bean adhesion molecule active in neural crest cells during embryonic development.CD146   acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Shih, I.M. (1999) J Pathol 189, 4-11.
2. Wang, P. et al. (2013) Mol Cell Biol 33, 3689-99.
Immunohistochemistry (Formalin/PFA-fixed paraffin embedded sections analysis of melanoma labelling CD146 with BP6162.

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