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Tim -3兔单克隆抗体

Tim -3兔单克隆抗体

一抗 抗体 试剂
  • 价格¥2200
  • 规格100ul
  • 货号HKZ150328
  • 单位支
  • 品牌HaoKebio
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HaoKebioHKZ150328Tim -3兔单克隆抗体100ul支2200
Tim-3
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  BX50205 Clone#  BP6182
Predicted Molecular Wt:
33kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q8TDQ0
Background:
T cell Ig- and mucin-domain-containing molecules (TIMs) area family of transmembrane proteins expressed by various
immune cells. TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer, and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype. TIM-3 is an inhibitory molecule that is
induced following T cell activation.Tumor-infiltrating dendritic cells (DCs) also express TIM-3. TIM-3 expression on DCs was
found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells. Research     studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer. In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease.
Subcellular location:
Membrane
Recommended method:  Heat induced epitope retrieval with Tris EDTA buffer                                                                                   
(pH 9.0), primary antibody incubate at RT (18°C-25°C)                                                                             
for 30 minutes.
 Immunogen:                                                                                                                                                                    Synthetic peptide corresponding to Human Tim-3 protein was used as an immunogen. The exact sequence is proprietary.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.                                                                                              
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1.  Monney, L. et al. (2002) Nature 415, 536-41.
2. Chiba, S. et al. (2012) Nat Immunol 13, 832-42.
3.Huang, Y.H. et al. (2015) Nature 517, 386-90.          
 Immunohistochemistry
(Formalin/PFA-fixed paraffin-embeddedsections) analysis of tonsillabelling Tim-3 withBP6182. Heat mediatedantigen retrieval was performed using
Tris/EDTA buffer pH 9.0
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