c -Myc兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150341
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150341	c -Myc兔单克隆抗体	100ul	支	1000

c-Myc
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50218 Clone# BP6195
Predicted Molecular Wt:
48kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P01106
Background:
Oncogene-encoded proteins c-Myc, n-Myc, and l-Myc function in cell proliferation, differentation and neoplastic disease. A mutated version of Myc is found in many cancers, which causes Myc to be constitutively expressed. This leads to the
unregulated expression of many genes, some of which are involved in cell proliferation, and result in the formation of cancer. c-Myc is a transcription factor and is a proto-oncogene that is the focal point in cell cycle regulation, metabolism, apoptosis,    differentiation, cell adhesion, and tumorigenesis.
A common human translocation involving Mycist(8;14), which is criticialto the development of most cases of Burkitt’s Lymphoma. Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung, and stomach.
Subcellular location:
Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide residues in human c-Myc was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1.  Hoffman B, et al. Oncogene. 2002; 21(21):3414-21.
2. Nakles R, et al. Mol Endocrinol. 2011; 25:549-63.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) analysis     of human Burkitt’s
lymphoma tissue labelling  c-Myc with BP6195. Heat    mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0

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