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IDH1 R132H兔单克隆抗体

IDH1 R132H兔单克隆抗体

一抗 抗体 试剂
  • 价格¥1000
  • 规格100ul
  • 货号HKZ150228
  • 单位支
  • 品牌HaoKebio
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HaoKebioHKZ150228IDH1 R132H兔单克隆抗体100ul支1000
IDH1 R132H
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  HKZ150228 Clone#  BP6205
Predicted Molecular Wt:
47kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  O75874
Background:
Heterozygous point mutations of IDH1 codon 132 are frequent in World Health Organization (WHO) grade II and III gliomas. IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. The high frequency and     distribution of the IDH1 R132H mutation among specific brain tumor entities allow the highly sensitive and specific
discrimination of various tumors by immunohistochemistry, such as anaplastic astrocytoma from primary glioblastoma or
diffuse astrocytoma WHO grade II from pilocytic astrocytoma or ependymoma. Noteworthy is the discrimination of the infiltrating edge of tumors with IDH1 mutation from reactive gliosis. This antibody is highly useful
for tumor classification and in detecting single infiltrating tumor cells. The routine practical approach for diagnosing astrocytomas and oligodendrogliomas begins with perfoming IHC for IDH1 R132H and ATRX expression.
Subcellular location:
Cytoplasm
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx and/or its suppliers.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1.  Reuss D etal.Acta Neuropathol. 129(1):133-146, 2015
2.  David NL etal. Acta Neuropathol. 131:803-820, 2016
Immunohistochemistry
(Formalin/PFA-fixed paraffin- embedded sections) analysis  of human  glioma (IDH1
R132H)  tissue labelling IDH1 R132H with BP6205. Heat
mediated antigen retrieval was performed using
Tris/EDTA buffer pH 9.0
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