TROP-2 Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# BX50231 Clone# BP6208 Predicted Molecular Wt: 36kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: P09758 Background: TROP-2 or Tumor-associated calcium signal transducer 2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This transmembrane glycoprotein functions in a variety of cell signaling pathways and was first elucidated as a transducer of an intracellular calcium signal.. TROP-2 is expressed in a variety of epithelial tissues and tumor tissues from which TROP2 originates, such as tonsil, esophagus, pancreatic, prostate and gastric cancers. TROP-2 has become a new target for researchers to develop antibody-conjugated drugs. TROP-2 is highly expressed in triple- negative breast cancer, non-small cell lung cancer, uroepithelial carcinoma and various types of solid tumors, and is expected Subcellular location: Membrane Recommended method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Synthetic peptide. This information is proprietary to Biolynx. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage conditions: -25°C to -18°C Storage instructions: Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles. Recommended Dilutions: IHC-P: 1:100-1:200 Background References: 1. McDougall, A.R. et al. (2015) Dev Dyn 244, 99-109. 2. Shvartsur, A. and Bonavida, B. (2015) Genes Cancer 6, 84-105. Immunohistochemistry (Formalin/PFA-fixed paraffin- embedded sections) analysis of human esophageal carcinoma tissue labelling TROP-2 with BP6208. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9.0
杭州浩克生物
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