NUT1兔单克隆抗体

价格¥1800
规格100ul
货号HKZ150367
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150367	NUT1兔单克隆抗体	100ul	支	1800

NUT1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50244 Clone# BP6221
Predicted Molecular Wt:
120kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q86Y26
Background:
Nuclear protein in testis (NUT1 or NUTM1) is a nuclear protein encoded by the NUTM1 gene on chromosome 15 and normally expressed in testicular tissues. NUT1 is an unstructured protein with few orthologs, and shuttles between the nucleus and
cytoplasm. NUT cancer (formerly NUT Midline Carcinoma) occurs after a gene fusion event between NUTM1 and often a
bromodomain (BRD) family gene in about 75% of cases. NUTM1 less commonly fuses with NSD3, MXD4, MGA, ZNF532, CIC, and other rare variants, which are all considered to be NUT cancers.
NUT cancers can be carcinomas, sarcomas, lymphomas, and other types of tumors, and are often formed in the head, neck, or mediastinum. However, primary cancers have been reported in kidney, bladder, lung, breast, and metastasis to lymph nodes    has also been seen for these very aggressive tumors.
NUT1 antibody is mainly used in the diagnosis of midline carcinoma.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues of NUT1 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. French, C.A. et al. (2003) Cancer Res 63, 304-7.
2. Haack, H. et al. (2009) Am J Surg Pathol 33, 984-91.
Immunohistochemistry (Formalin/PFA-fixed paraffin-
embedded sections) analysis of testis labelling NUT1 with BP6221.

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普通病理

分子病理

成像分析

分子生物

理化检测

蛋白生物学

细胞实验

普通形态

分子病理

分子生物学

抗体

蛋白质生物学

NUT1兔单克隆抗体

说明文档下载

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