TLE1 Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# HKZ150246 Clone# BP6223 Predicted Molecular Wt: 83kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: Q04724 Background: TLE1 binds to a number of transcription factors. It inhibits NF-kappa-B-regulated gene expression,also inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. It enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. TLE1 is wildly expressed in normal and cancer tissues. TLE1 is generally use for diagnosis of synovial sarcoma. Subcellular location: Nucleus Recommended Method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Full length protein corresponding to Human TLE1. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage Conditions: -25°C to -18°C Shipment Instructions: Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles. Recommended Dilution: IHC-P: 1:100-1:200 Background References: 1. Tetsuka T., Uranishi H., Imai H., Ono T., Sonta S. J. Biol. Chem. 275:4383-4390(2000) Immunohistochemistry (Formalin/PFA-fixed paraffin- embedded sections) analysis of synovial sarcoma labelling TLE1 with BP6223.
杭州浩克生物
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