GATA-3兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150375
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150375	GATA-3兔单克隆抗体	100ul	支	1000

GATA-3
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50252 Clone# BP6229
Predicted Molecular Wt:
48kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P23771
Background:
GATA binding protein 3 or GATA-3, is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.
GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is
considered a marker of luminal cancer in ER+ cancer and luminalandrogen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong
predictor of taxane and platin salts insensitivity.
GATA-3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, GATA-3 can be
used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder area
possibility. Studies have also shown the utility of GATA-3 in differntiatingurothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Voduc D, et al. Cancer Epidemiol Biomarkers Prev.
2008 Feb;17(2):365-73.
2. Miettinen M, et al. Am J Surg Pathol. 2014 Jan; 38(1): 13–22.
Immunohistochemistry (Formalin/PFA-fixed paraffin-
embedded sections) analysis of invasive ductal carcinoma of the breast labelling GATA-3 with BP6229.

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