CDK4兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150376
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150376	CDK4兔单克隆抗体	100ul	支	1000

CDK4
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50253 Clone# BP6230
Predicted Molecular Wt:
34kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P11802
Background:
Cyclin-dependent kinase-4 (CDK4) is a protein-serinekinase involved in the cell cycle. It is essential for the G1- to S-phase
transition during the cell cycle and its expression is primarily controlled at the transcriptional level (PMID:17253961). CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment   that are vital to sustain tumor outgrowth (PMID:21844184).
CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas, but rarely expressed in other benign liposarcomas and other sarcomas.
CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+), dedifferentiated liposarcoma (+) and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma and other high-grade sarcomas.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
A synthetic peptide corresponding to the N-term of CDK4 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1.  Ma L  etal. Oncotarget 8:4125-4135 (2017).
2. Lv XJ  et al. Oncol Rep N/A:N/A (2016).
Immunohistochemistry (Formalin/PFA-fixed paraffin- embedded sections) analysis of dedifferentiated
liposarcoma labelling CDK4 with BP6230.

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