Claudin18.2兔单克隆抗体

价格¥2200
规格100ul
货号HKZ150395
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150395	Claudin18.2兔单克隆抗体	100ul	支	2200

Claudin18.2
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50272 Clone# BP6249
Predicted Molecular Wt:
28kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P56856-2
Background:
Claudin18.2 (CLDN18.2) is a splice variant of the membrane epithelial tight junctions protein Claudin18 (CLDN18) and has
been identified as a promising biomarker for targeted therapy. While upon malignant transformation, the changes in cell
polarity lead to the exposure of CLDN18.2 epitopes.   which are suitable for targeted therapy. Prior evidence demonstrates     that except for GC, CLDN18.2 is aberrantly expressed in various primary tumors and metastases, including pancreatic, biliary, ovarian, and lung adenocarcinomas, which makes CLDN18.2 a pan-cancer target.
CLDN18.2 has a restricted expression profile in normal tissues, it physiologically expresses only in the tight junction supramolecular complex of gastric mucosa.
Subcellular location:
Membrane
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein fragment of human Claudin18.2 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Xu B  etal. J Gastrointest Oncol 11:1431-1439 (2020).
2.  Moentenich V  etal. Oncol Lett 19:3665-3670 (2020).
Immunohistochemistry (Formalin/PFA-fixed paraffin-
embedded sections) analysis of human stomach labelling Claudin18.2 with BP6249.

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