BAP-1兔单克隆抗体

价格¥2200
规格100ul
货号HKZ150401
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150401	BAP-1兔单克隆抗体	100ul	支	2200

BAP-1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50278 Clone# BP6255
Predicted Molecular Wt:
80kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q92560
Background:
BAP-1 (BRCA-1 Associated Protein-1) is an 80 kDa protein known to function as a deubiquitinase (DUB); removing ubiquitin modifiers, which alter the function of other proteins via targeted degradation, subcellular localization, or activity. By
removing ubiquitin, BAP-1 helps regulate the function of target proteins involved in diverse cellular processes.
BAP-1 was expressed in most normal cells, but deletion of expression has been found in mesothelioma.
Germline mutations in the BAP-1 gene have been associated with BAP-1 tumor predisposition syndrome, a condition linked to early onset and/or increased risk of multiple types of cancers including uveal melanoma, malignant mesothelioma, cutaneous  melanoma, and renal cell carcinoma.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Citterio E. Front Genet. 2015; 6:282.
2. Murali R, Wiesner T, Scolyer RA. Pathology. 2013 Feb; 45(2):116-26.
Immunohistochemistry (Formalin/PFA-fixed paraffin-   embedded sections) analysis of human mesothelioma labelling BAP-1 with BP6255.

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