MDR-1兔单克隆抗体

价格¥1800
规格100ul
货号HKZ150283
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150283	MDR-1兔单克隆抗体	100ul	支	1800

MDR-1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150283 Clone# BP6260
Predicted Molecular Wt:
141kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P08183
Background:
MDR1/ABCB1 belongs to the Mdr/Tap subfamily of the ATP-binding cassette transporter superfamily. Multidrug resistance 1
(MDR1) serves as an efflux pump for xenobiotic compounds with broad substrate specificity. MDR1 substrates include
therapeutic agents such as actinomycin D,etoposide, imatinib, and doxorubicin, as well as endogenous molecules including β- amyloids, steroid hormones, lipids, phospholipids, cholesterol, and cytokines. Intracellular MDR1 has been detected in the ER, vesicles, and nuclear envelope, and has been associated with cell trafficking machinery. Other reported functions of MDR1
include viral resistance, cytokine trafficking, and lipid homeostasis in the peripheral and central nervous system.
MDR1 expressed in the plasma membrane of cells in the blood-brain, blood-cerebral spinal fluid, or blood-placenta barriers    restricts the permeability of drugs into these organs from the apical or serosal side. MDR1 is also expressed in normal tissues with excretory function such as small intestine, liver, and kidney.
Research studies have shown that MDR1 reduces drug accumulation in cancer cells, allowing the development of drug resistance.
Subcellular location:
Membrane
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Miller, D.S. et al. (2008) Pharmacol Rev 60, 196-209.
2. Jeannesson, E. et al. (2009) Clin Chim Acta 403, 198-202.
Immunohistochemistry (Formalin/PFA-fixed paraffin-  embedded sections) analysis of human breast cancer labelling MDR-1 with BP6260.

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