Bcl-6兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150407
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150407	Bcl-6兔单克隆抗体	100ul	支	1000

Bcl-6
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50284 Clone# BP6261
Predicted Molecular Wt:
79kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P41182
Background:
Bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.The mitogen-activated protein kinases, Erk1 and Erk2, but not JNK, phosphorylate BCL6 at multiple sites. Phosphorylation of BCL6 at Ser333 and
Ser343 results in degradation of BCL6 by the ubiquitin/proteasome pathway in B cells. In addition, BCL6 is acetylated and its transcriptional repressor function is inhibited by the transcriptional co-activator p300.
Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in
Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease.
Bcl-6 combined with CD10 can be used to distinguish follicular lymphoma from other lymphomas. Bcl-6 combined with CD10 and MUM1 can be used for the classification of diffuse large B-cell lymphoma.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein fragment of Bcl-6 was used as an immunogen. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Shvarts, A. et al. (2002) Genes Dev 16, 681-6.
2. Bereshchenko, O.R. et al. (2002) Nat Genet 32, 606-13.
Immunohistochemistry (Formalin/PFA-fixed paraffin- embedded sections) analysis of human tonsil labelling Bcl- 6 with BP6261.

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