IMP-3兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150410
单位支
品牌HaoKebio

产品介绍

产品参数

资料下载

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150410	IMP-3兔单克隆抗体	100ul	支	1000

IMP-3
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50287 Clone# BP6264
Predicted Molecular Wt:
64kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  O00425
Background:
IMP-3 is RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). It also
modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from
endonuclease attacks or microRNA-mediated degradation. IMP-3 binds to N6-methyladenosine (m6A)-containing mRNAs and
increases their stability. IMP-3 Binds to the 3′-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells.
IMP-3 expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary, gonocytesoftestis, growing oocytes, spermatogonia and semen. It also expressed in ovary, testis, brain, placenta, pancreatic cancer tissues,
cervix adenocarcinoma, in testicular pancreatic and renal-cell carcinomas.
Multiple studies have found that IMP-3 is a marker of malignancy associated with increased tumor aggressiveness and decreased overall survival. It also can be used to distinguish pancreatic cancer from chronic sclerosing pancreatitis.
Subcellular location:
Cytoplasm/Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein fragment of IMP-3 was used as an immunogen. This information is proprietary to
Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. PMID: 16541107
2. PMID: 23640942
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreatic cancer labelling IMP-3     with BP6264.

HKZ150410_BP6264_IMP-3 下载

暂无