TIGIT兔单克隆抗体

价格¥2200
规格100ul
货号HKZ150295
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150295	TIGIT兔单克隆抗体	100ul	支	2200

TIGIT
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150295 Clone# BP6272
Predicted Molecular Wt:
26kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q495A1
Background:
T-cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSIG9, VSTM3, and WUCAM, is a member of the
poliovirus receptor family of immunoglobulin proteins. TIGIT marks exhausted T cells in the tumor microenvironment and     during human immunodeficiency virus (HIV) infection. Research has shown TIGIT interacts with several receptors expressed on antigen presenting cells, such as dendritic cells and macrophages, as well as tumor cells and cells of the
microenvironment. TIGIT binds with high affinity to PVR/CD155, and with low affinity to Nectin-2/CD112 and Nectin-3/CD113.
TIGIT is expressed at low levels on subsetsofT cells and NK cells, and is upregulated at the protein level following activation of these cells.
Subcellular location:
Membrane
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein fragment of human TIGIT was
used as an immunogen. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Levin, S.D. et al. (2011) Eur J Immunol 41, 902-15.
2. Chauvin, J.M. et al. (2015) J Clin Invest 125, 2046-58.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of  human tonsil labelling TIGIT with BP6272.

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