Claudin 6 Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# HKZ150297 Clone# BP6274 Predicted Molecular Wt: 23kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: P56747 Background: Claudin-6 is a member of the CLDN family that is expressed in epithelial cell sheets. Downregulation of Claudin-6 has been reported in breast invasive ductal carcinoma associated with lymphatic metastasis which may point to a function of Claudin-6 as a tumor suppressor. Claudin-6 is reported to play a role in inhibiting malignancy of breast cancer cells by inducing apoptosis, inhibiting proliferation and migration. Claudin6 is rarely expressed in normal tissue species, but is highly expressed in tumor cells, especially in ovarian cancer. Subcellular location: Membrane & Cytoplasm Recommended Method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Synthetic peptide. This information is proprietary to Biolynx. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage Conditions: -25°C to -18°C Shipment Instructions: Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles. Recommended Dilution: IHC-P: 1:100-1:200 Background References: 1. Shin, K. et al. (2006) Annu Rev Cell Dev Biol 22, 207-35. 2. Hewitt, K.J. et al. (2006) BMC Cancer 6, 186. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian cancer labelling Claudin 6 with BP6274.
杭州浩克生物
您好！请登录