CD3D兔单克隆抗体

价格¥600
规格100ul
货号HKZ150300
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150300	CD3D兔单克隆抗体	100ul	支	600

CD3D
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150300 Clone# BP6277
Predicted Molecular Wt:
19kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P04234
Background:
When T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery. This activation process depends mainly on CD3 (Cluster of
Differentiation 3),a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: ζ, γ, ε(CD3E), and δ (CD3D). Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif
(ITAM). Engagement of the TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and
phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and the p85 subunit of PI-3 kinase.
TCR ligation also induces a conformational change in CD3D, such that a proline region is exposed and then associates with the adaptor protein Nck.
CD3D is generally expressed in T cells and their source tumor cells.
Defects in CD3D area cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK- cell-positive (T(-)/B(+)/NK(+) SCID).
Subcellular location:
Membrane
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA
0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Kuhns, M.S. et al. (2006) Immunity 24, 133-139.
2. Pitcher, L.A. and van Oers, N.S. (2003) Trends Immunol. 24, 554- 560.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded
sections) analysis of  human tonsil labelling CD3D with BP6277.

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