Calreticulin兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150425
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150425	Calreticulin兔单克隆抗体	100ul	支	1000

Calreticulin
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50302 Clone# BP6279
Predicted Molecular Wt:
48kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P27797
Background:
Calcium is a universal signaling molecule involved in many cellular functions, such as cell motility, metabolism, protein
modification, et al. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin. Calreticulin also functions asan ER chaperone that ensures proper folding and quality
control of newly synthesized glycoproteins.
Calreticulin is expressed in all kinds of normal tissues and tumor tissues.
Calreticulin purified from tumor can stimulate the anti-tumor immune response of the body, the possible mechanism is that   the calreticulin molecule binds to the tumor antigen polypeptide, and in the process of calreticulinto the cell membrane, the tumor antigen peptide bound with it is brought to the cell membrane and presented to the antigen-presenting cell, thus
stimulating the anti-tumor immune effect of the body. Calreticulin purified from tumor can stimulate the anti-tumor immune  response of the body, the possible mechanism is that the calreticulin molecule binds to the tumor antigen polypeptide, and in the process of calreticulinto the cell membrane, the tumor antigen peptide bound with it is brought to the cell membrane
and presented to the antigen-presenting cell, thus stimulating the anti-tumor immune effect of the body.
Subcellular location:
Cytoplasm
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Groenendyk, J. et al. (2004) Mol Cells 17, 383-9.
2. Williams, D.B. (2006) J Cell Sci 119, 615-23.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate labelling Calreticulin with   BP6279.

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