Islet-1兔单克隆抗体

价格¥1800
规格100ul
货号HKZ150303
单位支
品牌HaoKebio

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品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150303	Islet-1兔单克隆抗体	100ul	支	1800

Islet-1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150303 Clone# BP6280
Predicted Molecular Wt:
39kDa
Purity:  ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:  Liquid
Applications:
IHC-P
Swissprot ID:  P61371
Background:
Islet-1,a human insulin gene enhancer-binding protein, is a transcription factor involved in the differentiation of the
neuroendocrine pancreatic cells. Islet-1 plays an important role in the embryogenesis and differentiation of the insulin
producing pancreatic beta cells within the islets of Langerhans. Neuroendocrine tumors can arise from a variety of primary     sites, most commonly in the bronchopulmonary system, gastrointestinal (GI) tract, and pancreas.Neuroendocrine tumors of  the GI tract and pancreas tend to be slow growing and indolent, and may metastasize to the liver before it is detected.Islet-1
exhibits strong nuclear staining in the islets of normal pancreas and tumor cells of the pancreatic neuroendocrine tumor. Islet-1 has been shown to be a reliable marker for the detection of primary and metastatic pancreatic neuroendocrine
neoplasms.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Schmitt AM, , et al. Am J Surg Pathol. 2008 Mar;32(3):420-5.
2. Ediger BN, et al. Diabetes. 2014 Dec;63(12):4206-17.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of of human pancreas tissue sections labeling Islet-1 with BP6280.

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