OCT3/4兔单克隆抗体

价格¥1000
规格100ul
货号HKZ150428
单位支
品牌HaoKebio

产品介绍

产品参数

资料下载

品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKZ150428	OCT3/4兔单克隆抗体	100ul	支	1000

OCT3/4
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# BX50305 Clone# BP6282
Predicted Molecular Wt:
39kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q01860
Background:
OCT-4, also known as OTF3 or POU5F1, is a member of the POU family of transcription factors, involved in the regulation of pluripotency during normal development and is detectable in embryonic stem and germ cells. It can specifically bind to the  octamer motif (5′-ATTTCAT-3′), and it is critical for the self-renewal of embryonic stem cells. OCT-4 is a key regulator of self- renewal in embryonic stem cells; its expression is potentially correlated with tumorigenesis and can affect some aspects of   tumor behavior such as tumor recurrence or resistance to therapies.
OCT-4 is a sensitive and specific marker for germ cell tumors. It is consistently detected in carcinoma in situ/gonadoblastoma,
seminomas, germinoma, dysgerminoma, and embryonal carcinoma but not in the differentiated components of nonseminomas.
An antibody to OCT-4 is useful in the identification of primary as well as metastatic germ cell tumors.
Subcellular location:
Nucleus
Recommended Method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage Conditions:
-25°C to -18°C
Shipment Instructions:
Shipped on blue ice. Upon delivery store at -25°C to – 18°C. Avoid freeze / thaw cycles.
Recommended Dilution:
IHC-P:     1:100-1:200
Background References:
1. Zhang S  et al. Nucleic Acids Res 47:4449-4461 (2019).
2. Chang YC  et al. Cell Death Dis 11:195 (2020).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human seminoma tissue labelling OCT3/4   with BP6282.

HKZ150428_BP6282_OCT3&4 下载

暂无